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Contact Us

NBIP Ireland
Research Office
121 St Stephens Green
Dublin 2
Ireland

nbipadmin@rcsi.ie
+353 1 402 8651



Email:
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Project Title:
Regulation of metabolism by 17beta-estradiol in breast cancer cells.

 

Host Laboratory: Royal College of Surgeons in Ireland, Molecular Medicine Laboratories, Education and Research Centre, Smurfit Building,Beaumont Hospital, Dublin 9,Ireland and University of California Irvine, 151 Medical Research Long Beach, VA Medical Centre,5901 E 7th Street, Long Beach, CA 90822, USA.

 

Research Interests: Apoptosis and Cancer, Cell Signalling and Molecular Endocrinology

 

Technical Expertise: Molecular and Cellular Imaging, Imaging & Data Analysis

 
Publications (2009-2011):

Articles:

- Barberine reduces cAMP-induced chloride secretion in T84 human colonic carcinoma cells through inhibition of basolateral KCNQ1 channels (2011) Frontiers in Membrane Physiology and Biophysics. In press

- Estrogen inhibits chloride secretion caused by cholera and Escherichia coli enterotoxins in female rat distal colon (2011) Alzamora R, O'Mahony F, Harvey BJ. Steroids May 8

- Estrogen receptor-{beta} prevents cardiac fibrosis (2010) Pedram A , Razandi M , O'Mahony F , Lubahn D , Levin ER. Molecular Endocrinology 24(11):2152-65

- Genomic priming of the 17beta-estradiol rapid anti-secretory response in rat distal colon throughout the estrous cycle (2009) O’Mahony F, Alzamora R, Harvey BJ Molecular Endocrinology. Nov; 23(11):1885-1899     

- Developmental phenotype of a membrane only estrogen receptor alpha (MOER) mouse Journal of Biological Chemistry (2009) Pedram A, Razandi M, Kim JK, O'Mahony F, Lee EYHP, Luderer U, Levin ER; 284(6):3488-95 PMID 19054762

  
Reviews:

Novel female sex-dependent actions of estrogen in the intestine (2009) O’Mahony F, Harvey BJ Journal of Physiology 587(Pt 21):5039-44 PMID: 19723780 

 
Current Status of Fellowship: Fiona completed her fellowship in July 2011. As of September 2011, she is working at University of California (UCLA), Los Angeles, Division of Digestive Diseases & Pfleger Liver Institute.