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Project Title: Development of novel PNA based molecular probes for the detection of c-Myc mRNA.

Host Laboratory: Royal College of Surgeons in Ireland, Department of Pharmaceutical and Medicinal Chemistry, 123 St Stephens Green, Dublin 2, Ireland and IBB-CNR, UOS Napoli Centro, via Mezzocannone 16, 80134 Naples, Italy.

Research Interests: Apoptosis and Cancer

Technical Expertise: Drug Designs and Molecular Models for Imaging Applications

Maria completed her CEMP fellowship in April 2011. She will be working at the Royal College of Surgeons in Ireland, Department of Pharmaceutical and Medicinal Chemistry, for another year.

  

Articles published during the CEMP fellowship: 

• Musumeci D.; Bucci E., Roviello G. N., Sapio R., Valente M., Moccia M., Bianchi M. E., Pedone C. (2011) DNA-based strategies for blocking HMGB1 cytokine activity: design, synthesis and preliminary in vitro/in vivo assays of DNA and DNA-like duplexes; Mol. Biosyst., DOI:10.1039/C1MB05009E
• Bruschi S.; Moccia M.; Mauro M. F. A. (2011) Studies on the reactivity of 3-methyl-4-nitro-5-styrylisoxazoles with S-Nucleophiles; Tetrahedron Lett.,52, accepted
• Mauro F.A. Adamo, Roberto Pergoli, Maria Moccia (2010) Alkynyl-2-deoxy-D-riboses, a cornucopia for the generation of families of C-nucleosides; Tetrahedron, Volume 66, Issue 47, 9242-9251
• Moccia M, Roviello GN, Bucci EM, Pedone C, Saviano (2010) Synthesis of a l-lysine-based alternate, epsilon-peptide: a novel linear polycation with nucleic acids-binding ability; M. Int J Pharm., 15; 397(1-2):179-83