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Contact Us

NBIP Ireland
Research Office
121 St Stephens Green
Dublin 2
Ireland

nbipadmin@rcsi.ie
+353 1 402 8651



Email:
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Project Title:
Investigating the role of the AIF/CypA complex in neuronal cell death and in cerebral hypoxic- ischemic injury

 

Host Laboratory: Royal College of Surgeons in Ireland, Department of Neurodegeneration, 123 St. Stephen's Green, Dublin 2, Ireland and Institutes of Biostructure and Bioimaging, via Mezzocannone 16, 80134 Naples, Italy.

 

Research Interests: Apoptosis and Cancer

 

Technical Expertise: Molecular and Cellular Imaging, Small Animal Imaging, Imaging & Data Analysis, Integration of Imaging Technologies and Methodologies, Drug Designs and Molecular Models for Imaging Applications, High Content Analysis


Publications:

Articles (2008-2010):

  • Protein-protein interactions: a simple strategy to identify binding sites and peptide antagonists (2009) Sandomenico A, Monti SM, Sabatella M, De Capua A, Tornatore L, Doti N, Viparelli F, Dathan NA, Pedone C, Ruvo M, Marasco D Chem Biol Drug Des 73(5):483-93 PMID: 19366357
  • Peptide antagonists of the PED-hPLD1 binding (2009) Viparelli F, Doti N, Monti SM, Marasco D, Dathan N, Pedone C, Miele C, Formisano P, Beguinot F, Ruvo M Adv Exp Med Biol 611:445-6 PMID: 19400259
  • Targeting of PED/PEA-15 molecular interaction with phospholipase D1 enhances insulin sensitivity in skeletal muscle cells (2008) Viparelli F, Cassese A, Doti N, Paturzo F, Marasco D, Dathan NA, Monti SM, Basile G, Ungaro P, Sabatella M, Miele C, Teperino R, Consiglio E, Pedone C, Beguinot F, Formisano P, Ruvo M J Biol Chem 283(31):21769-78 PMID: 18541525
  • Expression and purification of the D4 region of PLD1 and characterization of its interaction with PED-PEA15 (2008) Viparelli F, Doti N, Sandomenico A, Marasco D, Dathan NA, Miele C, Beguinot F, Monti SM, Ruvo M Protein Expr Purif 59(2):302-8 PMID: 18420420

Abstract Publication and Oral Communications:

  • Functional insights in SOCS1-JAK2 interaction: a combinational approach (2008) EIS Meeting, Rome, Italy

Posters (2008-2010):

  • Identification of inhibitors of protein-protein interactions through the screening of Simplified Combinatorial Peptide Libraries (2009) Scognamiglio PL, Doti N, Pedone C, Grieco P, Ruvo M, Marasco D American Peptide Symposium, Bloomington-America
  • A simple and versatile High Throughput (HT) assay for the screening of anti-aggregating compounds (2009) Doti N, Sabatella M, Marasco D, Ruvo M Innovative Methodologies and Technologies for Pharmaceutical Meeting, Verona, Italy
  • Insights into protein-protein interactions and identification of new ligands through combined binding experiments (2008) MarascoD, Doti N, Viparelli F, Sabatella M, Minchiotti G, Ruvo M Biacore Interaction Days, Italy
  • L’inibizione dell’interazione molecolare di PED/PEA-15 con la fosfolipasi D1 migliora la sensibilità all’insulina in cellule muscolo scheletriche (2008) Cassese A, Paturzo F, Doti N, Ilardi A, Nigro C, Per ruolo G, Botta G, Luppoli GA, Miele C, Formisano P, Ruvo M, Beguinot F XXII SID, Italy
  • Protein-protein interactions and peptide antagonists (2008) Ruvo M, Monti SM, Doti N, Viparelli F, Sandomenico A, Tornatore L, Marasco D, Italy
  • Identificazione d’inibitori di complessi proteina-proteina mediante un approccio combinatoriale (2008) Scognamiglio PL, Marasco D, Grieco P, Pedone C, Ruvo M Doti N Scientific days, University of Naples “Federico II”, Italy
  • An analysis of deletion mutants of the PLD1 D4 domain defines short regions within the PLD1 interacting with PED/PEA-15: implications for the development of peptides-specific antagonist (2008) Doti N, Marasco D, Sabatella M, Monti SM, Dathan N, Viparelli F, Cassese A, Miele C, Pedone C, Ruvo M EPS, Finland
  • A peptide from the N-terminal region of PED/PEA-15 blocks its interaction with PLD1 and restores insulin sensitivity in skeletal muscle cells (2008) Viparelli F, Paturzo F, Doti N, Cassese A, Marasco D, Dathan NA, Monti SM, Sabatella M, Miele C, Beguinot F, Formisano P, Ruvo M 33rd FEBS Congress - 11th IUBMB conference on Biochemistry of Cell Regulation. Athens, Greece
  • An analysis of deletion mutants of the PLD1 D4 domain defines short regions within the PLD1 interacting with PED/PEA-15: implications for the development of peptides-specific antagonist (2008) Doti N, Marasco D, Sabatella M, Monti SM, Dathan N, Viparelli F, Cassese A , Miele C, Pedone C, Ruvo M 11h Naples Work shop on Bioactive Peptides, Italy


Current Status of Fellowship:
Nunzianna completed her fellowship in September 2011. She is continuing her research at the Institutes of Biostructure and Bioimaging - CNR in Naples.