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NBIP Ireland
Research Office
121 St Stephens Green
Dublin 2
Ireland

nbipadmin@rcsi.ie
+353 1 402 8651


Dynamic changes during thrombosis and atherogenesis

 

Team: Niamh Moran (RCSI), Alice Stanton (RCSI), Noel Caplice (UCC), Dermot Kenny (RCSI), Robert Forster (DCU), Tia Keyes (DCU) Brian MacCraith (DCU), John Morrisson (UCC); Patrick Harriott (QUB), Paul Whelan (DCU)

This reseach aims to exploit the role of the blood platelet in cardiovascular disease, and apply our knowledge, resources, and assessment of clinical needs, for therapeutic and diagnostic gains.
We are:

  • Developing novel bio-mimetic peptides conjugates incorporating environmentally-sensitive luminescent ruthenium, osmium and iridium dyes with long-lived excited states Establishing FRET imaging techniques, and developing FLIM and resonant Raman technologies, to study platelet events in haemostasis and thrombosis
  • Developing multimodality approaches, e.g. confocal laser scanning fluorescence microscopy/spectroscopy/luminescent lifetime imaging; combined fluorescence/resonance Raman imaging and AFM/Raman imaging
  • Conjugating dyes and dye-doped nanoparticles appropriating tags for detection of platelet function in various relevant biological assays
  • Testing and selecting optimal dye-conjugates and doped-nanoparticle-conjugates for platelet labelling in ex-vivo systems and in small and large animal models, in association with the Human vascular Ultrasound imaging core at RCSI and the PET-CT scanner at UCC
  • Developing physical infrastructure at DCU, UCC and RCSI to underpin these studies
  • Developing systems in association with CIPA(DCU) for computer assisted detection of key events

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