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NBIP Ireland
Research Office
121 St Stephens Green
Dublin 2
Ireland

nbipadmin@rcsi.ie
+353 1 402 8651


Responses to steroid hormones and secretagogues

Team: Brian Harvey, Peter Dockery, Laurence Egan, Garret Fitzgerals, Vincenet Healy, Edward Johns, Stephen Keely, Cathal Kelly, Hugh Byrne, Fiona Lyng, Warren Thomas, Tytus Bernas, Ruth Dooley, Fional O'Mahony, Gianpiero Cavalleri, Valia Verriere, Rick Chung, Marie Schaeffer, Patrice Mollard, Margaret Lucitt, Caroline Jefferies, Kevin Stacey, Taoufik El Yandouzi, Chris Thompson, Manuel Yamil Jusef Robles, Noel McHale, Bernard Drumm,Valerie Urbach, Raphael Rapitte Mauss

The research programme in molecular endocrinology is focused on understanding the cellular and molecular mechanisms by which steroid hormones affect key physiological processes in regulating salt absorption in the kidney and chloride secretion in the intestine and lung. The pathologies resulting from dysregulation of these signalling pathways are hypertension (kidney), secretory diarrhoea (intestine) and cystic fibrosis (lung). We are also testing hypotheses of aldosterone and estrogen induced cell proliferation and tumorigenesis occurring via novel protein kinases in polycystic kidney disease, and in colorectal and breast cancer.

The research projects combine the use of a confocal laser scanning microscope and molecular biology approaches to dissect the cell signalling pathways following hormone binding to its receptor and downstream genomic events and regulation of the activity of membrane transport proteins and other receptors. The information gained from these studies will lead to a better understanding of how steroids effect changes in electrolyte transport, cell proliferation and to identify potential targets for therapeutic intervention.


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5um cryosection of rat kidney stained with actin (green), DAPI (blue) and aquaporin 2 (red)

Image by Dr Ruth Dooley, Department of Molecular Medicine, Royal College of Surgeons in Ireland